Overview

  • Product nameAnti-Saporin antibody (HRP)
    See all Saporin primary antibodies
  • Description
    Goat polyclonal to Saporin (HRP)
  • ConjugationHRP
  • Specificityab42903 recognises saporin.
  • Tested applicationsSuitable for: IHC-Frmore details
  • Species reactivity
    Reacts with Saponaria officinalis (Soapwort). Not yet tested in other species.
  • Immunogen

    Chemical/ Small Molecule corresponding to Saporin.

  • General notes

    The antibody was coupled to Horseradish Peroxidase (HRP) and dialysed against PBS.

Properties

Applications

Our Abpromise guarantee covers the use of ab42903 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr 1/350 - 1/1000.

Target

  • RelevanceSaporin is obtained from the seeds of the Soapwort plant (Saponaria officinalis), a plant that grows wildly in Britain and other parts of Europe. Saporin is a plant enzyme with N-glycosidase activity that depurinates a specific nucleotide in the ribosomal RNA 28S, thus irreversibly blocking protein synthesis. It belongs to the well-characterized family of ribosome-inactivating proteins (RIPs). There are two types of RIPs: type I, which are much less cytotoxic due to the lack of the B chain and type II, which are distinguished from type I RIPs by the presence of the B chain and their ability to enter cells on their own. However, type I RIPs can still be internalized by fluid-phase endocytosis. In the case of saporin, it was reported that saporin first binds to the alpha 2 macroglobulin receptor on human cells and is then internalized to the cytosol. Upon internalization, the ribosomes are inactivated, resulting in cell death. Among all type I RIPs saporin SO6 is the most widely used because it is easily obtainable and very stable.
  • Alternative names
    • Saporin antibody

References for Anti-Saporin antibody (HRP) (ab42903)

ab42903 has not yet been referenced specifically in any publications.

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