• Product name
  • Description
    Rabbit polyclonal to SAR1B
  • Tested applications
    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide derived from internal sequence of human SAR1B.

  • Positive control
    • Human placenta tissue. Extracts from LOVO and RAW264.7 cells.



Our Abpromise guarantee covers the use of ab74046 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 22 kDa (predicted molecular weight: 22 kDa).
ELISA 1/20000.
IHC-P 1/50 - 1/100.


  • Function
    Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex.
  • Tissue specificity
    Expressed in many tissues including small intestine, liver, muscle and brain.
  • Involvement in disease
    Defects in SAR1B are the cause of chylomicron retention disease (CMRD) [MIM:246700]; also known as Anderson disease (ANDD). CMRD is an autosomal recessive disorder of severe fat malabsorption associated with failure to thrive in infancy. The condition is characterized by deficiency of fat-soluble vitamins, low blood cholesterol levels, and a selective absence of chylomicrons from blood. Affected individuals accumulate chylomicron-like particles in membrane-bound compartments of enterocytes, which contain large cytosolic lipid droplets.
  • Sequence similarities
    Belongs to the small GTPase superfamily. SAR1 family.
  • Cellular localization
    Endoplasmic reticulum membrane. Golgi apparatus > Golgi stack membrane. Associated with the endoplasmic reticulum and Golgi stacks, in particular in the juxta-nuclear Golgi region.
  • Information by UniProt
  • Database links
  • Alternative names
    • ANDD antibody
    • CMRD antibody
    • GTBPB antibody
    • GTP binding protein SAR1b antibody
    • GTP binding protein Sara antibody
    • GTP-binding protein B antibody
    • GTP-binding protein SAR1B antibody
    • SAR1 gene homolog B (S. cerevisiae) antibody
    • SAR1 homolog B antibody
    • SAR1a gene homolog 2 antibody
    • SAR1B antibody
    • SAR1B_HUMAN antibody
    • SARA2 antibody
    • SARB antibody
    see all

Anti-SAR1B antibody images

  • All lanes : Anti-SAR1B antibody (ab74046) at 1/500 dilution

    Lane 1 : Extracts from LOVO cells
    Lane 2 : Extracts from RAW264.7 cells
    Lane 3 : Extracts from LOVO cells with immunising peptide at 5 µg

    Lysates/proteins at 5 µg per lane.

    Predicted band size : 22 kDa
    Observed band size : 22 kDa
    Additional bands at : 21 kDa,27 kDa,35 kDa,40 kDa,55 kDa,87 kDa. We are unsure as to the identity of these extra bands.
  • Immunohistochemistry analysis of paraffin-embedded human placenta tissue using ab74046, at 1/50 dilution, in the presence (right panel) or absence (left panel) of immunising peptide.

References for Anti-SAR1B antibody (ab74046)

ab74046 has not yet been referenced specifically in any publications.

Product Wall

Merci pour votre appel de hier.

Je peux vous confirmer que nos deux anticorps contre le SAR1B ne vont pas crossréagir avec le SAR1A. Ceci n'a pas spécifiquement été testé à ma connaissance, mais les i...

Read More


Sign up