Overview

  • Product nameAnti-SAR1B antibody
    See all SAR1B primary antibodies
  • Description
    Goat polyclonal to SAR1B
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Rat
    Predicted to work with: Human
  • Immunogen

    Synthetic peptide:

    DHERLLESKEELD

    , corresponding to internal sequence amino acids 104-116 of Human SAR1B (NP_001028675.1; NP_057187.1)

  • Positive control
    • Mouse and Rat Liver lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab77279 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notesPeptide ELISA: antibody detection limit dilution: 1/8000.
    WB: Use at a concentration of 0.03 - 0.1 µg/ml. Detects a band of approximately 25 kDa (predicted molecular weight: 22 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionInvolved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex.
    • Tissue specificityExpressed in many tissues including small intestine, liver, muscle and brain.
    • Involvement in diseaseDefects in SAR1B are the cause of chylomicron retention disease (CMRD) [MIM:246700]; also known as Anderson disease (ANDD). CMRD is an autosomal recessive disorder of severe fat malabsorption associated with failure to thrive in infancy. The condition is characterized by deficiency of fat-soluble vitamins, low blood cholesterol levels, and a selective absence of chylomicrons from blood. Affected individuals accumulate chylomicron-like particles in membrane-bound compartments of enterocytes, which contain large cytosolic lipid droplets.
    • Sequence similaritiesBelongs to the small GTPase superfamily. SAR1 family.
    • Cellular localizationEndoplasmic reticulum membrane. Golgi apparatus > Golgi stack membrane. Associated with the endoplasmic reticulum and Golgi stacks, in particular in the juxta-nuclear Golgi region.
    • Information by UniProt
    • Database links
    • Alternative names
      • ANDD antibody
      • CMRD antibody
      • GTBPB antibody
      • GTP binding protein SAR1b antibody
      • GTP binding protein Sara antibody
      • GTP-binding protein B antibody
      • GTP-binding protein SAR1B antibody
      • SAR1 gene homolog B (S. cerevisiae) antibody
      • SAR1 homolog B antibody
      • SAR1a gene homolog 2 antibody
      • SAR1B antibody
      • SAR1B_HUMAN antibody
      • SARA2 antibody
      • SARB antibody
      see all

    Anti-SAR1B antibody images

    References for Anti-SAR1B antibody (ab77279)

    ab77279 has not yet been referenced specifically in any publications.

    Product Wall

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"