Anti-SARS Nucleocapsid Protein antibody (ab26854)

Overview

  • Product name
    Anti-SARS Nucleocapsid Protein antibody
  • Description
    Mouse polyclonal to SARS Nucleocapsid Protein
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    SARS virus.
  • Immunogen

    Synthetic peptide: GQGVPINTNS GPDDQIGYYR RATRRVRGGD GKMKELSPRW YFYYLGTGPE ASLPYGANKE GIVWVATEGA LNTPKDHIGT RNPNNNAATV LQLPQGTTLP, corresponding to N terminal amino acids 70-169 of SARS Nucleocapsid Protein.

Properties

Applications

Our Abpromise guarantee covers the use of ab26854 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
WB 1/500. Predicted molecular weight: 46 kDa.

Target

  • Relevance
    Severe Acute Respiratory Syndrome (SARS), an emerging disease characterized by atypical pneumonia, has recently been attributed to a novel coronavirus (SARS-CoV). SARS is caused by a human coronavirus, which are the major cause of upper respiratory tract illness in humans, such as the common cold. Coronaviruses are positive stranded RNA viruses, featuring the largest viral RNA genomes known to date (27-31 kb). The spike protein is the main surface antigen of the coronavirus. The most prominent protein in the culture supernatants infected with SARS virus is a 46 kDa nucleocapsid protein. This suggests that the nucleocapsid protein is a major immunogen that may be useful for early diagnostics. The nucleocapsid protein of SARS shares little homology with nucleocapsid proteins of other members of the coronavirus family. Nucleocapsid proteins of other coronavirus have been reported to be involved in forming the viral core and also in the packaging and transcription of the viral RNA.
  • Cellular localization
    Inside the virion, complexed with the viral RNA. May be associated with cellular membranes where it participates in viral RNA synthesis and virus budding.
  • Alternative names
    • N antibody
    • NC antibody
    • Nucleocapsid protein antibody
    • Nucleoprotein antibody
    • Protein N antibody
    • SARS coronavirus N protein antibody
    • SARS CoV antibody
    see all

Images

  • Anti-SARS Nucleocapsid Protein antibody (ab26854) at 1/500 dilution + 400ng of recombinant SARS CoV Nucleocapsid protein

    Secondary
    HRP conjugated anti mouse IgG

    Predicted band size : 46 kDa
    Observed band size : 60 kDa (why is the actual band size different from the predicted?)

References

ab26854 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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