Overview

  • Product name
  • Description
    Goat polyclonal to SART3
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    MSNADFAKLFLRK

    , corresponding to C terminal amino acids 951-963 of Human SART3

  • Positive control
    • Lysates of cell lines Daudi, Jurkat and MOLT4.

Properties

Applications

Our Abpromise guarantee covers the use of ab36137 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
WB
  • Application notes
    Peptide ELISA: antibody detection limit dilution 1:16,000.
    WB: Use at a concentration of 0.01 - 0.03 µg/ml. Predicted molecular weight: 110 kDa. (predicted molecular weight: 110 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication.
    • Tissue specificity
      Ubiquitously expressed.
    • Involvement in disease
      Defects in SART3 are the cause of disseminated superficial actinic porokeratosis type 1 (DSAP1) [MIM:175900]. DSAP1 is an autosomal dominant disorder, characterized by multiple superficial keratotic lesions surrounded by a slightly raised keratotic border, developing during the third or fourth decade of life on sun-exposed areas of skin.
    • Sequence similarities
      Contains 8 HAT repeats.
      Contains 2 RRM (RNA recognition motif) domains.
    • Post-translational
      modifications
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localization
      Cytoplasm. Nucleus speckle. Localized in speckles. Expressed in the nucleus of all of the malignant tumor cell lines tested and the majority of cancer tissues with various histologies, including squamous cell carcinomas (SCC), adenocarcinomas, melanomas and leukemias cells. However, this protein is undetectable in the nucleus of any cell lines of nonmalignant cells or normal tissues, except for the testis. Expressed in the cytoplasm of all the proliferating cells, including normal and malignant cells, but not in normal tissues, except for the testis and the fetal liver.
    • Information by UniProt
    • Database links
    • Alternative names
      • DSAP1 antibody
      • hSART 3 antibody
      • hSART-3 antibody
      • P100 antibody
      • P110 antibody
      • p110(nrb) antibody
      • RP11 13G14 antibody
      • SART 3 antibody
      • SART-3 antibody
      • SART3 antibody
      • SART3_HUMAN antibody
      • Squamous cell carcinoma antigen recognized by T cells 3 antibody
      • Squamous cell carcinoma antigen recognized by T-cells 3 antibody
      • Tat interacting protein of 110 kDa antibody
      • Tat-interacting protein of 110 kDa antibody
      • Tip110 antibody
      see all

    Images

    References

    This product has been referenced in:
    • Long L  et al. The U4/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitination. J Biol Chem 289:8916-30 (2014). WB . Read more (PubMed: 24526689) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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