Overview

  • Product nameAnti-SART3 antibody
    See all SART3 primary antibodies
  • Description
    Rabbit polyclonal to SART3
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Orangutan
  • Immunogen

    Synthetic peptide corresponding to a region between residue 600 and 650 of Human SART3 (NP_055521.1)

  • Positive control
    • Human Controls: Breast Carcinoma, Colon Carcinoma, Linitis Plastica Stomach Cancer, Ovarian Carcinoma, Pancreatic Islet Cell Tumor, Prostate Carcinoma, Skin Basal Cell Carcinoma, Stomach Adenocarcinoma, Testicular Seminoma

Properties

Applications

Our Abpromise guarantee covers the use of ab84671 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: 1/100 - 1/500.

    Epitope exposure with citrate buffer will enhance staining and is recommended.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionRegulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication.
    • Tissue specificityUbiquitously expressed.
    • Involvement in diseaseDefects in SART3 are the cause of disseminated superficial actinic porokeratosis type 1 (DSAP1) [MIM:175900]. DSAP1 is an autosomal dominant disorder, characterized by multiple superficial keratotic lesions surrounded by a slightly raised keratotic border, developing during the third or fourth decade of life on sun-exposed areas of skin.
    • Sequence similaritiesContains 8 HAT repeats.
      Contains 2 RRM (RNA recognition motif) domains.
    • Post-translational
      modifications
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localizationCytoplasm. Nucleus speckle. Localized in speckles. Expressed in the nucleus of all of the malignant tumor cell lines tested and the majority of cancer tissues with various histologies, including squamous cell carcinomas (SCC), adenocarcinomas, melanomas and leukemias cells. However, this protein is undetectable in the nucleus of any cell lines of nonmalignant cells or normal tissues, except for the testis. Expressed in the cytoplasm of all the proliferating cells, including normal and malignant cells, but not in normal tissues, except for the testis and the fetal liver.
    • Information by UniProt
    • Database links
    • Alternative names
      • DSAP1 antibody
      • hSART 3 antibody
      • hSART-3 antibody
      • P100 antibody
      • P110 antibody
      • p110(nrb) antibody
      • RP11 13G14 antibody
      • SART 3 antibody
      • SART-3 antibody
      • SART3 antibody
      • SART3_HUMAN antibody
      • Squamous cell carcinoma antigen recognized by T cells 3 antibody
      • Squamous cell carcinoma antigen recognized by T-cells 3 antibody
      • Tat interacting protein of 110 kDa antibody
      • Tat-interacting protein of 110 kDa antibody
      • Tip110 antibody
      see all

    Anti-SART3 antibody images

    • ab84671 at 1/100 dilution, staining SART3 in Formalin-Fixed Paraffin-Embedded Human pancreatic islet cell tumor tissue by Immunofluorescence. Detection: Redfluorescent goat anti-rabbit IgG highly cross-adsorbed Antibody at a dilution of 1/100.
    • ab84671 at 1/100 dilution, staining SART3 in Formalin-Fixed Paraffin-Embedded Human pancreatic islet cell tumor tissue by Immunohistochemistry. Detection: DAB staining
    • ab84671 at 1/250 dilution, staining SART3 in Formalin-Fixed Paraffin-Embedded Human pancreatic islet cell tumor tissue by Immunohistochemistry. Detection: DAB staining

    References for Anti-SART3 antibody (ab84671)

    ab84671 has not yet been referenced specifically in any publications.

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