The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/100 - 1/500. Epitope exposure with citrate buffer will enhance staining.
FunctionMay have a role in a signaling pathway. Could act as a tumor suppressor.
Tissue specificityExpressed ubiquitously, with highest levels in lung, placenta, spleen and thymus. Down-regulated in the majority (74%) of breast tumors in comparison with corresponding normal breast epithelial tissues.