Overview

  • Product nameAnti-SAV1 antibody
    See all SAV1 primary antibodies
  • Description
    Mouse monoclonal to SAV1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: HTAEIPDWLQ VYARAPVKYD HILKWELFQL ADLDTYQGML KLLFMKELEQ IVKMYEAYRQ ALLTELENRK QRQQWYAQQH GKNF, corresponding to amino acids 300-384 of Human SAV1

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • IsotypeIgG2a
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab57534 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionRegulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.
    • Tissue specificityUbiquitously expressed in adult tissues with highest expression in the pancreas, aorta and interventricular septum and lowest expression in skeletal muscle. Expression was higher in fetal than in the adult heart. Expressed in various cell lines.
    • Sequence similaritiesContains 1 SARAH domain.
      Contains 2 WW domains.
    • Post-translational
      modifications
      Phosphorylated by STK3/MST2 and STK4/MST1. Phosphorylation is not required for SAV1 stability and may increase the number of protein binding sites on the scaffold molecule.
    • Cellular localizationNucleus. Cytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • 1700040G09Rik antibody
      • 45 kDa WW domain protein antibody
      • hWW 45 antibody
      • hWW45 antibody
      • Protein salvador homolog 1 antibody
      • salvador family WW domain containing protein 1 antibody
      • salvador homolog 1 (Drosophila) antibody
      • Salvador homolog 1 antibody
      • Salvador, Drosophila, homolog of antibody
      • SAV 1 antibody
      • SAV antibody
      • SAV1 antibody
      • SAV1_HUMAN antibody
      • WW 45 antibody
      • WW domain containing antibody
      • WW domain-containing adaptor 45 antibody
      • WW domain-containing protein, 45-KD antibody
      • WW45 antibody
      • WW45 protein antibody
      • WWP 4 antibody
      • WWP4 antibody
      see all

    Anti-SAV1 antibody images



    • Predicted band size : 45 kDa
      SAV1 antibody (ab57534) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    References for Anti-SAV1 antibody (ab57534)

    ab57534 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"