Overview

  • Product name
    SB 200646 hydrochloride
  • Description
    Selective 5-HT2C/2B receptor antagonist
  • Biological description
    Selective 5-HT2C/2B receptor antagonist. Prevents ethanol-induced, Ca2+-dependent miniature inhibitory postsynaptic currents. Shows anxiolytic effects in vivo. Orally active.
  • Purity
    > 98%

Properties

  • Chemical name
    N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea hydrochloride
  • Molecular weight
    302.76
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C15H14N4O.HCl
  • CAS Number
    143797-62-0
  • PubChem identifier
    5311422
  • Storage instructions
    Store at room temperature.
  • Solubility overview
    Soluble in DMSO to 100 mM
  • Handling

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CN1C=CC2=C1C=CC(=C2)NC(=O)NC3=CN=CC=C3.Cl
  • Source

    Synthetic

References

This product has been referenced in:
  • Theile JW  et al. Role of 5-hydroxytryptamine2C receptors in Ca2+-dependent ethanol potentiation of GABA release onto ventral tegmental area dopamine neurons. J Pharmacol Exp Ther 329:625-33 (2009). Read more (PubMed: 19225162) »
  • Xiao Y  et al. Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling. Mol Pain 4:12 (2008). Read more (PubMed: 18416824) »
  • Blackburn TP  et al. The acute and chronic administration of the 5-HT(2B/2C) receptor antagonist SB-200646A significantly alters the activity of spontaneously active midbrain dopamine neurons in the rat: An in vivo extracellular single cell study. Synapse 59:502-12 (2006). Read more (PubMed: 16565966) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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