Overview

  • Product name
    SB 204741
  • Description
    Selective 5-HT2B receptor antagonist
  • Biological description
    Selective 5-HT2B receptor antagonist. High affinity for 5-HT2B receptors (pKi = 7.85), some activity at 5-HT2C receptors (pKi = 5.8).
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Dergacheva O  et al. 5-HT(2) receptor subtypes mediate different long-term changes in GABAergic activity to parasympathetic cardiac vagal neurons in the nucleus ambiguus. Neuroscience 149:696-705 (2007). Read more (PubMed: 17869437) »
  • Shingala JR & Balaraman R Antihypertensive effect of 5-HT1A agonist buspirone and 5-HT2B antagonists in experimentally induced hypertension in rats. Pharmacology 73:129-39 (2005). Read more (PubMed: 15539790) »
  • Knowles ID & Ramage AG Evidence that activation of central 5-HT(2B) receptors causes renal sympathoexcitation in anaesthetized rats. Br J Pharmacol 129:177-83 (2000). Read more (PubMed: 10694218) »
  • Forbes IT  et al. N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea: a novel, high-affinity 5-HT2B receptor antagonist. J Med Chem 38:855-7 (1995). Read more (PubMed: 7699699) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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