Overview

  • Product nameSB 216763
  • Description
    Potent selective GSK3 inhibitor
  • Biological descriptionPotent and selective GSK3 inhibitor (Ki= 9 nM for GSK-3α). Has little activity against 24 other protein kinases (IC50 > 10 μM). Stimulates glycogen synthesis, gene transcription and is cardio- and neuroprotective.
  • Purity> 98%

Properties

  • Chemical name3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
  • Molecular weight371.22
  • Chemical structureChemical Structure
  • Molecular formulaC19H12Cl2N2O2
  • CAS Number280744-09-4
  • PubChem identifier176158
  • Storage instructionsStore at +4°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overviewSoluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESClc1ccc(c(Cl)c1)C=4C(=O)NC(=O)C=4c3cn(C)c2ccccc23
  • Source

    Synthetic

  • Research areas

    References for SB 216763 (ab120202)

    This product has been referenced in:
    • Gross ER  et al. Delayed cardioprotection afforded by the glycogen synthase kinase 3 inhibitor SB-216763 occurs via a KATP- and MPTP-dependent mechanism at reperfusion. Am J Physiol Heart Circ Physiol 294:H1497-500 (2008). Read more (PubMed: 18223186) »
    • Zhu LQ  et al. Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments. J Neurosci 27:12211-20 (2007). Read more (PubMed: 17989287) »
    • Coghlan MP  et al. Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem Biol 7:793-803 (2000). Read more (PubMed: 11033082) »

    See 1 Publication for this product

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    Our biochemical compounds are not made in a sterile environment, and as such we would recommend that sterilisation measures are taken prior to use, if a sterile solution is needed.


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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"