Overview

  • Product nameSB 225002
  • Description
    A selective non-peptide CXCR2 antagonist
  • Biological descriptionA selective non-peptide CXCR2 antagonist. Inhibits IL-8 binding to CXCR2 (IC50 = 22 nM).
  • Purity> 95%

Properties

  • Chemical nameN-(2-Bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)urea
  • Molecular weight352.14
  • Chemical structureChemical Structure
  • Molecular formulaC13H10BrN3O4
  • CAS Number182498-32-4
  • Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overviewSoluble in DMSO to 75 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESOC1=CC([N+]([O-])=O)=CC=C1NC(NC2=C(Br)C=CC=C2)=O
  • Source

    Synthetic

  • Research areas

    References for SB 225002 (ab120895)

    This product has been referenced in:
    • Catusse J  et al. Characterization of the molecular interactions of interleukin-8 (CXCL8), growth related oncogen alpha (CXCL1) and a non-peptide antagonist (SB 225002) with the human CXCR2. Biochem Pharmacol 65:813-21 (2003). Read more (PubMed: 12628493) »
    • Lane BR  et al. Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy. J Virol 75:8195-202 (2001). Read more (PubMed: 11483765) »
    • White JR  et al. Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J Biol Chem 273:10095-8 (1998). Read more (PubMed: 9553055) »

    See 0 Publications for this product

    Product Wall

    We can only advise based on literature and unfortunately I was unable to find anything specifically on the interaction of SB225002 and the anesthetics mentioned. However, looking at the literature, compounds such as Isoflurane, ketamine and xylazine se...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"