Overview

  • Product nameSB 269970 hydrochloride
  • Description
    Potent, selective 5-HT7 receptor antagonist
  • Biological descriptionPotent, selective 5-HT7 receptor antagonist (pKi values are 8.3, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B receptors, respectively). Also potently blocks α2 adrenoceptors. Blocks amphetamine and ketamine induced hyperactivity. Brain penetrant in vivo.
  • Purity> 98%

Properties

    References for SB 269970 hydrochloride (ab120508)

    This product has been referenced in:
    • Galici R  et al. Effects of SB-269970, a 5-HT7 receptor antagonist, in mouse models predictive of antipsychotic-like activity. Behav Pharmacol 19:153-9 (2008). Read more (PubMed: 18332680) »
    • Roberts C  et al. The effect of SB-269970, a 5-HT(7) receptor antagonist, on 5-HT release from serotonergic terminals and cell bodies. Br J Pharmacol 132:1574-80 (2001). Read more (PubMed: 11264252) »
    • Hagan JJ  et al. Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonist. Br J Pharmacol 130:539-48 (2000). Read more (PubMed: 10821781) »

    See 0 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab120508.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"