Overview

  • Product name
    SB 334867
  • Description
    Selective OX1 receptor antagonist
  • Biological description
    Selective OX1 receptor antagonist. Inhibits orexin-A induced intracellular calcium release (IC50 = 226 nM). Shows anxiolytic, sedative and anorectic effects in vivo.
  • Purity
    > 99%

Properties

  • Chemical name
    N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-ylurea
  • Molecular weight
    319.32
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C17H13N5O2
  • CAS Number
    792173-99-0
  • PubChem identifier
    6604926
  • Storage instructions
    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in ethanol to 10 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CC1=NC2=C(O1)C=C(C=C2)NC(=O)NC3=C4C(=NC=C3)C=CC=N4
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Staples LG & Cornish JL The orexin-1 receptor antagonist SB-334867 attenuates anxiety in rats exposed to cat odor but not the elevated plus maze: an investigation of Trial 1 and Trial 2 effects. Horm Behav 65:294-300 (2014). Read more (PubMed: 24397997) »
  • Azhdari-Zarmehri H  et al. Orexin receptor type-1 antagonist SB-334867 decreases morphine-induced antinociceptive effect in formalin test. Pharmacol Biochem Behav 112:64-70 (2013). Read more (PubMed: 24125787) »
  • Smart D  et al. SB-334867-A: the first selective orexin-1 receptor antagonist. Br J Pharmacol 132:1179-82 (2001). Read more (PubMed: 11250867) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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