Overview

  • Product name
    SB-3CT
  • Description
    Potent, competitive and non-selective MMP-2 and MMP-9 inhibitor
  • Biological description
    Potent, competitive and non-selective MMP-2 and MMP-9 inhibitor (Ki values are 13.9 and 600 nM for MMP-2 and MMP-9 respectively). Does not alter the activity of MMP-1, MMP-3 or MMP-7 (Ki values are 206 (MMP-1), 15 (MMP-3) and 96 (MMP-7) μM). Neuroprotective and blood-brain barrier permeable.
  • Purity
    > 98%

Properties

References

This product has been referenced in:
  • Gooyit M  et al. Selective gelatinase inhibitor neuroprotective agents cross the blood-brain barrier. ACS Chem Neurosci 3:730-6 (2012). Read more (PubMed: 23077716) »
  • Ranasinghe HS  et al. Inhibition of MMP-9 activity following hypoxic ischemia in the developing brain using a highly specific inhibitor. Dev Neurosci 34:417-27 (2012). Read more (PubMed: 23171520) »
  • Zhang H  et al. Role of matrix metalloproteinases and therapeutic benefits of their inhibition in spinal cord injury. Neurotherapeutics 8:206-20 (2011). Read more (PubMed: 21455784) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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