Human Predicted to work with:
Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig
Synthetic peptide corresponding to a region within internal sequence amino acids 318-367 (PGMQESADKP TRRENPHKYL LYKPTFSQLY TFLAASFKEL PANSVLLIYL) of Human SCAI (NP_775961; UniProt ID: Q8N9R8 isoform 2).
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 µg/ml. Predicted molecular weight: 73 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
FunctionTumor suppressor which functions to suppress MKL1-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1.
Sequence similaritiesBelongs to the SCAI family.
Cellular localizationMembrane. Nucleus. Cytoplasm. Nuclear localization is required for inhibition of MKL1.