Overview

  • Product nameAnti-SCDGFB antibody
    See all SCDGFB primary antibodies
  • Description
    Rabbit polyclonal to SCDGFB
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cat
  • Immunogen

    Synthetic peptide from within N terminal amino acids 35-83: ANLRRDESNH LTDLYRRDET IQVKGNGYVQ SPRFPNSYPR NLLLTWRLHS, of Human SCDGFB (NP_079484)

  • Positive control
    • Human fetal heart lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab94782 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 43 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionPotent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound. Activated by proteolytic cleavage and this active form acts as a specific ligand for beta platelet-derived growth factor receptor. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis.
  • Tissue specificityExpressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in placenta, liver, kidney, prostate, testis, small intestine, spleen and colon. In the kidney, expressed by the visceral epithelial cells of the glomeruli. A widespread expression is also seen in the medial smooth muscle cells of arteries and arterioles, as well as in smooth muscle cells of vasa rectae in the medullary area. Expressed in the adventitial connective tissue surrounding the suprarenal artery. In chronic obstructive nephropathy, a persistent expression is seen in glomerular visceral epithelial cells and vascular smooth muscle cells, as well as de novo expression by periglomerular interstitial cells and by some neointimal cells of arteriosclerotic vessels. Expression in normal prostate is seen preferentially in the mesenchyme of the gland while expression is increased and more profuse in prostate carcinoma. Expressed in many ovarian, lung, renal and brain cancer-derived cell lines.
  • Sequence similaritiesBelongs to the PDGF/VEGF growth factor family.
    Contains 1 CUB domain.
  • Developmental stageNot detectable in the earliest stages of glomerulogenesis, and not detected in the metanephric blastema or surrounding cortical interstitial cells. In later stages of glomerulogenesis, localized to epithelial cells transitioning from the early developing nephrons of the comma- and S-shaped stages to the visceral epithelial cells of differentiated glomeruli. In the developing pelvis, expressed at the basement membrane of immature collecting ducts and by presumptive fibroblastic cells in the interstitium.
  • Post-translational
    modifications
    Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after Arg-247 or Arg-249 by urokinase plasminogen activator gives rise to the active form.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • IEGF antibody
    • Iris expressed growth factor antibody
    • Iris-expressed growth factor antibody
    • MGC26867 antibody
    • MSTP036 antibody
    • PDGF D antibody
    • PDGF-D antibody
    • PDGFD antibody
    • PDGFD latent form antibody
    • PDGFD receptor-binding form antibody
    • PDGFD_HUMAN antibody
    • Platelet derived growth factor D antibody
    • Platelet-derived growth factor D antibody
    • receptor-binding form antibody
    • rSCDGF-B antibody
    • SCDGF B antibody
    • SCDGF-B antibody
    • Spinal cord derived growth factor B antibody
    • Spinal cord-derived growth factor B antibody
    • spinal-cord derived growth factor-B protein antibody
    see all

Anti-SCDGFB antibody images

  • Anti-SCDGFB antibody (ab94782) at 1 µg/ml + Human fetal heart lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 43 kDa

References for Anti-SCDGFB antibody (ab94782)

ab94782 has not yet been referenced specifically in any publications.

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