• Product name
    Anti-SCF antibody (Biotin)
    See all SCF primary antibodies
  • Description
    Goat polyclonal to SCF (Biotin)
  • Conjugation
  • Tested applications
    Suitable for: WB, ELISA, Sandwich ELISAmore details
  • Species reactivity
    Reacts with: Rat
  • Immunogen

    Highly pure (>98%) recombinant full length Rat SCF



Our Abpromise guarantee covers the use of ab84436 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Sandwich ELISA
  • Application notes
    ELISA: Use at a concentration of 0.25 - 1 µg/ml. Allows the detection of at least 0.2 - 0.4 ng/well of recombinant Rat SCF.
    sELISA: Use at a concentration of 0.25 - 1 µg/ml. Allows the detection of at least 0.2 - 0.4 ng/well of recombinant Rat SCF.
    WB: Use at a concentration of 0.1 - 0.2 µg/ml. Detection limit for recombinant Rat SCF is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions. Predicted molecular weight: 31 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
    • Involvement in disease
      Hyperpigmentation with or without hypopigmentation, familial progressive
      Deafness, congenital, unilateral or asymmetric
    • Sequence similarities
      Belongs to the SCF family.
    • Developmental stage
      Acts in the early stages of hematopoiesis.
    • Post-translational
      A soluble form (sKITLG) is produced by proteolytic processing of isoform 1 in the extracellular domain.
      Found in two differentially glycosylated forms, LMW-SCF and HMW-SCF. LMW-SCF is fully N-glycosylated at Asn-145, partially N-glycosylated at Asn-90, O-glycosylated at Ser-167, Thr-168 and Thr-180, and not glycosylated at Asn-97 or Asn-118. HMW-SCF is N-glycosylated at Asn-118, Asn-90 and Asn-145, O-glycosylated at Ser-167, Thr-168 and Thr-180, and not glycosylated at Asn-97.
      A soluble form exists as a cleavage product of the extracellular domain.
    • Cellular localization
      Secreted; Cell membrane and Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Cell projection, lamellipodium. Cell projection, filopodium.
    • Information by UniProt
    • Database links
    • Alternative names
      • C kit ligand antibody
      • C-kit ligand antibody
      • Ckit ligand antibody
      • DCUA antibody
      • DFNA69 antibody
      • DKFZp686F2250 antibody
      • familial progressive hyperpigmentation 2 antibody
      • FPH2 antibody
      • FPHH antibody
      • KIT ligand antibody
      • Kitl antibody
      • KITLG antibody
      • KL 1 antibody
      • KL1 antibody
      • Mast cell growth factor antibody
      • MGF antibody
      • MGF stem cell factor antibody
      • SCF antibody
      • SCF_HUMAN antibody
      • SF antibody
      • SHEP7 antibody
      • sKITLG antibody
      • Soluble KIT ligand antibody
      • Steel factor antibody
      • steel, mouse, homolog of antibody
      • Stem cell factor antibody
      • Stem cell factor precursor antibody
      see all

    References for Anti-SCF antibody (Biotin) (ab84436)

    ab84436 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab84436.
    Please use the links above to contact us or submit feedback about this product.


    Sign up