Overview

  • Product name
  • Description
    Goat polyclonal to SCGF beta
  • Tested applications
    Suitable for: ELISA, Neutralising, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Highly pure (>98%) recombinant hSCGFb (human Stem Cell Growth Factor beta)

Properties

  • Form
    Lyophilised:Reconstitute with 200µl of sterile water.
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer
    PBS, pH 7.4, no preservative, sterile filtered
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    unknown
  • Light chain type
    unknown
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab9835 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use a concentration of 0.5 µg/ml. Allows the detection of 0.2 - 0.4 ng/well of recombinant hSCGFb.
Neutralising Use a concentration of 2.5 - 5 µg/ml. for one-half maximal inhibition [ND50] of the biological activity of hSCGFb (30.00 ng/ml).
WB Use a concentration of 0.1 - 0.2 µg/ml.

Target

  • Function
    Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation.
  • Tissue specificity
    Expressed in skeletal tissues including bone marrow, chondrocytes, primary ossification center-associated cells, the perichondrium and periosteum. Lower levels of expression were detected in spleen, thymus, appendix and fetal liver.
  • Sequence similarities
    Contains 1 C-type lectin domain.
  • Developmental stage
    In the bone marrow, expression is limited to immature neutrophils. Expression was not detected in circulating mature neutrophils.
  • Post-translational
    modifications
    O-glycosylated. Probably sulfated on the O-glycans.
  • Cellular localization
    Cytoplasm. Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • C type lectin domain family 11 member A antibody
    • C type lectin superfamily member 3 antibody
    • C-type lectin domain family 11 member A antibody
    • C-type lectin superfamily member 3 antibody
    • CLC11_HUMAN antibody
    • CLEC11A antibody
    • CLECSF3 antibody
    • LSLCL antibody
    • Lymphocyte secreted C type lectin antibody
    • Lymphocyte secreted C-type lectin antibody
    • p47 antibody
    • Stem cell growth factor antibody
    see all

References

This product has been referenced in:
  • Hiraoka A Leukemia cell lines require self-secreted stem cell growth factor (SCGF) for their proliferation. Leuk Res 32:1623-5 (2008). Human . Read more (PubMed: 18289675) »

See 1 Publication for this product

Customer reviews and Q&As

Thank you for contacting us. At Abcam we aim to provide our customers with a wide range of products to fit our researchers needs, and this somtimes results in very similar antibodies in our catalog. These two antibodies are both goat polyclonal with th...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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