SpecificityThis antibody is has been designed to recognise mouse Slfn8 (NP_853523), however it MAY recognise mouse Slfn-10 (AAP30073) and mouse Slfn-9 (AAP30071) based on their similarity at the C-terminus.
Predicted to work with:
, corresponding to C terminal amino acids 897-910 of Mouse Schlafen 8
Application notesThis antibody gave a positive result in ELISA against the immunising peptide.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined bu the end user.
RelevanceThe regulatory networks governing development and differentiation of hematopoietic cells are incompletely understood. Members of the Schlafen protein family have been implicated in the regulation of cell growth and T cell development. Four new members, Schlafen 5, Schlafen 8, Schlafen 9 and Schlafen 10, which belong to a distinct subgroup within this gene family have been identified and chromosomally mapped. The characteristic feature of these proteins is the presence of sequence motifs identifying them as distinct members of the superfamily I of DNA/RNA helicases.