Overview

  • Product name
  • Description
    Rabbit polyclonal to SCIN
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Cow
  • Immunogen

    Recombinant protein fragment corresponding to a region within amino acids 281 and 555 of Human SCIN.

  • Positive control
    • HepG2 whole cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab96105 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 80 kDa.

Target

  • Function
    Ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes.
  • Sequence similarities
    Belongs to the villin/gelsolin family.
    Contains 6 gelsolin-like repeats.
  • Cellular localization
    Cytoplasm, cytoskeleton.
  • Information by UniProt
  • Database links
  • Alternative names
    • Adseverin antibody
    • ADSV_HUMAN antibody
    • KIAA1905 antibody
    • Scin antibody
    • Scinderin antibody
    see all

Images

  • Anti-SCIN antibody (ab96105) at 1/1000 dilution + HepG2 cell lysate at 30 µg

    Predicted band size : 80 kDa

References

ab96105 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Abcam has not validated the combination of species/application used in this Abreview.
Application
Western blot
Sample
Bos taurus Cell lysate - whole cell (Chondrocytes)
Gel Running Conditions
Reduced Denaturing (10% gel)
Loading amount
10 µg
Specification
Chondrocytes
Blocking step
BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 23°C
Username

Byron Chan

Verified customer

Submitted Nov 21 2017

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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