Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Strongly expressed in heart, muscle and pancreas. Weakly expressed in brain, placenta, lung, liver and kidney.
Belongs to the SCM family. Contains 2 MBT repeats. Contains 1 SAM (sterile alpha motif) domain.
Immunoprecipitation of SCMH1 in HeLa whole cell lysate using 2.5µg ab153937. Lane 1: 40 µg of HeLa whole cell lysate. Lane 2: Control with 2.5 µg of preimmune rabbit IgG. Lane 3: Immunoprecipitation of SCMH1 protein. Western blot detection with ab153937 at 1/1000 dilution.