Overview

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • IsotypeIgG2a
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab56959 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionThis protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization.
    • Tissue specificityExpressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta.
    • Involvement in diseaseNeuropathy, hereditary sensory and autonomic, 7
      Episodic pain syndrome, familial, 3
    • Sequence similaritiesBelongs to the sodium channel (TC 1.A.1.10) family. Nav1.9/SCN11A subfamily.
    • DomainThe sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
    • Post-translational
      modifications
      Phosphorylation at Ser-1341 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • hNaN antibody
      • NaN antibody
      • NAV1.9 antibody
      • Peripheral nerve sodium channel 5 antibody
      • PN 5 antibody
      • PN5 antibody
      • SCN 11A antibody
      • SCN 12A antibody
      • Scn11a antibody
      • SCN12A antibody
      • SCNBA_HUMAN antibody
      • Sensory neuron sodium channel 2 antibody
      • SNS 2 antibody
      • SNS2 antibody
      • Sodium channel protein type 11 subunit alpha antibody
      • Sodium channel protein type XI subunit alpha antibody
      • Sodium channel voltage gated type XI alpha antibody
      • Sodium channel voltage gated type XI alpha polypeptide antibody
      • Sodium channel voltage gated type XI alpha subunit antibody
      • Sodium channel voltage gated type XII alpha polypeptide antibody
      • Voltage gated sodium channel Nav1.9 antibody
      • Voltage gated sodium channel subunit alpha Nav1.9 antibody
      • Voltage-gated sodium channel subunit alpha Nav1.9 antibody
      see all

    Anti-SCN11A antibody images

    • Western blot against tagged recombinant protein immunogen using ab56959 SCN11A antibody at 1ug/ml. Predicted band size of immunogen is 33 kDa

    References for Anti-SCN11A antibody (ab56959)

    ab56959 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab56959.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"