• Product nameAnti-SCN1B antibody
    See all SCN1B primary antibodies
  • Description
    Rabbit polyclonal to SCN1B
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Chimpanzee
  • Immunogen

    Synthetic peptide: ITNVTYNHSG DYECHVYRLL FFENYEHNTS VVKKIHIEVV DKANRDMASI , corresponding to internal sequence amino acids 109-158 of Human SCN1B

  • Positive control
    • HeLa cell lysate


Associated products


Our Abpromise guarantee covers the use of ab80390 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 25 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

ELISA titre using peptide based assay: 1:62500.


  • FunctionCrucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.
  • Tissue specificityAbundantly expressed in skeletal muscle, heart and brain.
  • Involvement in diseaseDefects in SCN1B are the cause of generalized epilepsy with febrile seizures plus type 1 (GEFS+1) [MIM:604233]. Generalized epilepsy with febrile seizures-plus refers to a rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity.
    Defects in SCN1B are the cause of Brugada syndrome type 5 (BRS5) [MIM:612838]. A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.
  • Sequence similaritiesBelongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • GEFSP1 antibody
    • SCN1B antibody
    • SCN1B_HUMAN antibody
    • sodium channel beta 1 subunit antibody
    • Sodium channel subunit beta 1 antibody
    • Sodium channel subunit beta-1 antibody
    • Sodium channel voltage gated type I beta antibody
    • Sodium channel voltage gated type I beta subunit antibody
    see all

Anti-SCN1B antibody images

  • Anti-SCN1B antibody (ab80390) at 1 µg/ml (in 5% skim milk / PBS buffer) + HeLa cell lysate at 10 µg

    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 25 kDa
    Observed band size : 25 kDa
    Additional bands at : 60 kDa. We are unsure as to the identity of these extra bands.

References for Anti-SCN1B antibody (ab80390)

ab80390 has not yet been referenced specifically in any publications.

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