• Product nameAnti-SCN1B antibody
    See all SCN1B primary antibodies
  • Description
    Rabbit polyclonal to SCN1B
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A synthetic peptide corresponding to a sequence at the N-terminal of Human SCN1B

  • Positive control
    • Rat brain and testicular tissue lysates; MCF7, HeLa, MM231 and HT1080 whole cell lysates.



Our Abpromise guarantee covers the use of ab86931 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 25 kDa (predicted molecular weight: 25 kDa).


  • FunctionCrucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.
  • Tissue specificityAbundantly expressed in skeletal muscle, heart and brain.
  • Involvement in diseaseDefects in SCN1B are the cause of generalized epilepsy with febrile seizures plus type 1 (GEFS+1) [MIM:604233]. Generalized epilepsy with febrile seizures-plus refers to a rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity.
    Defects in SCN1B are the cause of Brugada syndrome type 5 (BRS5) [MIM:612838]. A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.
  • Sequence similaritiesBelongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • GEFSP1 antibody
    • SCN1B antibody
    • SCN1B_HUMAN antibody
    • sodium channel beta 1 subunit antibody
    • Sodium channel subunit beta 1 antibody
    • Sodium channel subunit beta-1 antibody
    • Sodium channel voltage gated type I beta antibody
    • Sodium channel voltage gated type I beta subunit antibody
    see all

Anti-SCN1B antibody images

  • All lanes : Anti-SCN1B antibody (ab86931) at 1 µg/ml

    Lane 1 : Rat brain tissue lysate
    Lane 2 : Rat testicular tissue lysate
    Lane 3 : MCF7 whole cell lysate
    Lane 4 : HeLa whole cell lysate
    Lane 5 : MM231 whole cell lysate
    Lane 6 : HT1080 whole cell lysate

    Predicted band size : 25 kDa
    Observed band size : 25 kDa

References for Anti-SCN1B antibody (ab86931)

ab86931 has not yet been referenced specifically in any publications.

Product Wall

Application Western blot
Loading amount 50 µg
Gel Running Conditions Non-reduced Non-Denaturing (Native)
Sample Rat Cell lysate - whole cell (cardiamyocyte)
Specification cardiamyocyte
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 0.05% · Temperature: RT°C

Mr. Kuihao Chen

Verified customer

Submitted Dec 18 2013