• Product nameAnti-SCN3B antibody
  • Description
    Rabbit polyclonal to SCN3B
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Rat, Human
    Predicted to work with: Mouse, Cow
  • Immunogen

    A region within synthetic peptide: RPEGGKDFLI YEYRNGHQEV ESPFQGRLQW NGSKDLQDVS ITVLNVTLND, corresponding to amino acids 65-114 of Human SCN3B

  • Positive control
    • Fetal brain lysate.



Our Abpromise guarantee covers the use of ab48552 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 µg/ml. Detects a band of approximately 24 kDa (predicted molecular weight: 24 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • FunctionModulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.
  • Involvement in diseaseDefects in SCN3B are the cause of Brugada syndrome type 7 (BRGDA7) [MIM:613120]. A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.
  • Sequence similaritiesBelongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 1110001K16Rik antibody
    • 4833414B02Rik antibody
    • HSA243396 antibody
    • KIAA1158 antibody
    • MGC136997 antibody
    • MGC80155 antibody
    • Scn3b antibody
    • SCN3B_HUMAN antibody
    • SCNB3 antibody
    • Sodium channel subunit beta-3 antibody
    • Sodium channel, beta 3 subunit antibody
    • sodium channel, voltage-gated, type III, beta antibody
    see all

Anti-SCN3B antibody images

  • Anti-SCN3B antibody (ab48552) at 0.5 µg/ml + fetal brain lysate at 10 µg with 5% skimmed milk in PBS buffer

    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 24 kDa
    Observed band size : 24 kDa

References for Anti-SCN3B antibody (ab48552)

This product has been referenced in:
  • Ho C  et al. Differential expression of sodium channel ß subunits in dorsal root ganglion sensory neurons. J Biol Chem : (2012). WB ; Rat . Read more (PubMed: 22408255) »
  • Hu D  et al. A mutation in the beta 3 subunit of the cardiac sodium channel associated with Brugada ECG phenotype. Circ Cardiovasc Genet 2:270-8 (2009). WB ; Human . Read more (PubMed: 20031595) »

See all 2 Publications for this product

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