Overview

Description

  • NatureSynthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab4926 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Additional notes


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human SCNN1B, catalog ab2906. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

General Info

  • Alternative names
    • Amiloride sensitive sodium channel subunit beta
    • Amiloride-sensitive sodium channel subunit beta
    • Beta NaCH
    • Beta-ENaC
    • Beta-NaCH
    • ENaC beta
    • ENaCB
    • Epithelial Na(+) channel subunit beta
    • Epithelial Na+ channel beta subunit
    • Epithelial Na+ channel subunit beta
    • Epithelial sodium channel beta 2 subunit
    • Epithelial sodium channel beta 3 subunit
    • Nonvoltage gated sodium channel 1 beta subunit
    • Nonvoltage gated sodium channel 1 subunit beta
    • Nonvoltage-gated sodium channel 1 subunit beta
    • SCNEB
    • SCNN 1B
    • SCNN1B
    • SCNNB_HUMAN
    • Sodium channel nonvoltage gated 1 beta
    • Sodium channel nonvoltage gated 1 beta (Liddle syndrome)
    see all
  • FunctionSodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
  • Involvement in diseasePseudohypoaldosteronism 1, autosomal recessive
    Liddle syndrome
    Bronchiectasis with or without elevated sweat chloride 1
  • Sequence similaritiesBelongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1B subfamily.
  • Post-translational
    modifications
    Phosphorylated on serine and threonine residues.
  • Cellular localizationApical cell membrane. Apical membrane of epithelial cells.
  • Information by UniProt

References for SCNN1B peptide (ab4926)

ab4926 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"