Overview

  • Product name
    Anti-SCO1 antibody
  • Description
    Rabbit polyclonal to SCO1
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to 19 amino acids from near the center of Human SCO1.

  • Positive control
    • IHC-P: Human Heart and Human Brain Cortex tissues

Properties

Applications

Our Abpromise guarantee covers the use of ab115873 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 34 kDa.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copper into the active site of COX.
  • Tissue specificity
    Predominantly expressed in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain.
  • Involvement in disease
    Defects in SCO1 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome.
  • Sequence similarities
    Belongs to the SCO1/2 family.
  • Cellular localization
    Mitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cytochrome oxidase deficient homolog antibody
    • Cytochrome oxidase deficient homolog 1 antibody
    • Protein SCO1 homolog mitochondrial antibody
    • Protein SCO1 homolog, mitochondrial antibody
    • SCO (cytochrome oxidase deficient yeast) homolog 1 antibody
    • SCO cytochrome oxidase deficient homolog 1 (yeast) antibody
    • SCO cytochrome oxidase deficient homolog 1 antibody
    • sco1 antibody
    • SCO1_HUMAN antibody
    • SCOD1 antibody
    see all

Images

  • Human Heart (formalin-fixed, paraffin-embedded) stained with ab115873 at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with ab115873 at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References

ab115873 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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