• Product name
  • Description
    Mouse polyclonal to SCO1
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length Human protein (NP_004580.1)

  • Positive control
    • WB: lysate from Human liver or HeLa cells. ICC/IF: HepG2 cells.



Our Abpromise guarantee covers the use of ab88658 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 34 kDa.
ICC/IF Use a concentration of 10 µg/ml.


  • Function
    Thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copper into the active site of COX.
  • Tissue specificity
    Predominantly expressed in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain.
  • Involvement in disease
    Defects in SCO1 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome.
  • Sequence similarities
    Belongs to the SCO1/2 family.
  • Cellular localization
  • Information by UniProt
  • Database links
  • Alternative names
    • Cytochrome oxidase deficient homolog antibody
    • Cytochrome oxidase deficient homolog 1 antibody
    • Protein SCO1 homolog mitochondrial antibody
    • Protein SCO1 homolog, mitochondrial antibody
    • SCO (cytochrome oxidase deficient yeast) homolog 1 antibody
    • SCO cytochrome oxidase deficient homolog 1 (yeast) antibody
    • SCO cytochrome oxidase deficient homolog 1 antibody
    • sco1 antibody
    • SCO1_HUMAN antibody
    • SCOD1 antibody
    see all

Anti-SCO1 antibody images

  • ab88658 at 10 µg/ml staining SCO1 by immunofluorescence in paraformaldehyde fixed, permeabilized HepG2 cells.
  • Anti-SCO1 antibody (ab88658) at 1 µg/ml + Human liver lysate at 50 µg

    Predicted band size : 34 kDa
  • Anti-SCO1 antibody (ab88658) at 1 µg/ml + HeLa cell lysate at 50 µg

    Predicted band size : 34 kDa
  • All lanes : Anti-SCO1 antibody (ab88658) at 1 µg/ml

    Lane 1 : SCO1 transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Predicted band size : 34 kDa
    Observed band size : 33 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 27 kDa. We are unsure as to the identity of these extra bands.

References for Anti-SCO1 antibody (ab88658)

ab88658 has not yet been referenced specifically in any publications.

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