Overview

  • Product nameAnti-SCO2 antibody
    See all SCO2 primary antibodies
  • Description
    Rabbit polyclonal to SCO2
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to 19 amino acids from near the C-terminus of Human SCO2.

  • Positive control
    • IHC-P: Human Lung, Respiratory Epithelium and Human Kidney tissues

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab115877 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 30 kDa.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionActs as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2).
  • Tissue specificityUbiquitous.
  • Involvement in diseaseDefects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC) [MIM:604377]. This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies.
  • Sequence similaritiesBelongs to the SCO1/2 family.
    Contains 1 thioredoxin domain.
  • Cellular localizationMitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cytochrome oxidase deficient homolog 2 antibody
    • MGC125823 antibody
    • MGC125825 antibody
    • OTTHUMP00000196774 antibody
    • OTTHUMP00000196775 antibody
    • Protein SCO2 homolog, mitochondrial antibody
    • SCO (cytochrome oxidase deficient, yeast) homolog 2 antibody
    • SCO 1L antibody
    • SCO 2 antibody
    • SCO cytochrome oxidase deficient homolog 2 (yeast) antibody
    • SCO cytochrome oxidase deficient homolog 2 antibody
    • SCO1L antibody
    • SCO2 antibody
    • SCO2_HUMAN antibody
    • Synthesis of cytochrome c oxidase 2 antibody
    see all

Anti-SCO2 antibody images

  • Human Lung, Respiratory Epithelium (formalin-fixed, paraffin-embedded) stained with ab115877 at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • Human Kidney (formalin-fixed, paraffin-embedded) stained with ab115877 at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References for Anti-SCO2 antibody (ab115877)

ab115877 has not yet been referenced specifically in any publications.

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