Overview

  • Product nameAnti-ScpA antibody
  • Description
    Rabbit polyclonal to ScpA
  • Tested applicationsSuitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Staphylococcus aureus
  • Immunogen

    Synthetic peptide corresponding to C terminal residues of Staphylococcus aureus ScpA

Properties

Applications

Our Abpromise guarantee covers the use of ab92983 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/2000 - 1/5000.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 44 kDa. for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.

Target

  • RelevanceScpA (Staphylococcal cysteine proteinase A) is able to degrade elastin. ScpA (Staphylococcal cysteine proteinase A) has a broad endopeptidase action on proteins including elastin, but rather limited hydrolysis of small-molecule substrates. Assays are conveniently made with hemoglobin, casein or Z-Phe-Arg-NHMec as substrate. Prematurely activated/folded staphopain A is inhibited by staphostatin A (scpB), which is probably required to protect staphylococcal cytoplasmic proteins from degradation by scpA. In the cytoplasm, prematurely activated/folded scpA forms a stable non-covalent complex with scpB. Cleavage leads to the activation of scpA probably by an auto-catalytic manner. The catalytic maturation of scpA appears to reside outside the cascade of activation started by the metalloprotease aureolysin (aur) scpA (Staphylococcal cysteine proteinaseA) belongs to the peptidase C47 family.
  • Cellular localizationSecreted
  • Database links
    • Alternative names
      • sspB2 antibody
      • sspP antibody
      • Staphopain A antibody
      • Staphylococcal cysteine proteinase A antibody
      • Staphylopain A antibody
      see all

    References for Anti-ScpA antibody (ab92983)

    ab92983 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"