Overview

  • Product name
    Anti-Scramblase 1 antibody
    See all Scramblase 1 primary antibodies
  • Description
    Rabbit polyclonal to Scramblase 1
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within N terminal amino acids 1-256 of Human Scramblase 1

  • Positive control
    • 293T, A431, H1299, HeLa S3, HepG2, Molt-4 cells, MDAMB468 xenograft

Properties

Applications

Our Abpromise guarantee covers the use of ab96318 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 35 kDa.
IHC-P 1/100 - 1/500.

Target

  • Function
    May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
    May play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation.
  • Tissue specificity
    Expressed in platelets, erythrocyte membranes, lymphocytes, spleen, thymus, prostate, testis, uterus, intestine, colon, heart, placenta, lung, liver, kidney and pancreas. Not detected in brain and skeletal muscle.
  • Sequence similarities
    Belongs to the phospholipid scramblase family.
  • Post-translational
    modifications
    Known to be palmitoylated at one, yet undefined, site.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Ca(2+) dependent phospholipid scramblase 1 antibody
    • Ca(2+)-dependent phospholipid scramblase 1 antibody
    • Erythrocyte phospholipid scramblase antibody
    • MM1 cell-derived transplantability-associated gene 1b, mouse, homolog of antibody
    • MmTRA1a antibody
    • MmTRA1b antibody
    • Nor1 antibody
    • Phospholipid scramblase 1 antibody
    • PL scramblase 1 antibody
    • PLS1_HUMAN antibody
    • PLSCR 1 antibody
    • Plscr1 antibody
    • Scramblase1 antibody
    • Tra1 antibody
    • Tra1a antibody
    • Tra1b antibody
    • Transplantability-associated protein 1 antibody
    • Tras1 antibody
    • Tras2 antibody
    see all

Images

  • Anti-Scramblase 1 antibody (ab96318) at 1/1000 dilution + HeLa S3 whole cell lysate at 30 µg

    Predicted band size : 35 kDa
  • Immunohistochemical analysis of paraffin-embedded MDAMB468 xenograft, using ab96318 at 1/500 dilution.

References

This product has been referenced in:
  • Berghold VM  et al. Phospholipid scramblase 1 (PLSCR1) in villous trophoblast of the human placenta. Histochem Cell Biol 143:381-96 (2015). Read more (PubMed: 25362260) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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