Anti-SCRIBBLE antibody [EPR4140(2)] (ab125080)


  • Product name
    Anti-SCRIBBLE antibody [EPR4140(2)]
    See all SCRIBBLE primary antibodies
  • Description
    Rabbit monoclonal [EPR4140(2)] to SCRIBBLE
  • Tested applications
    Suitable for: WB, ICC, Flow Cytmore details
    Unsuitable for: IHC-P or IP
  • Species reactivity
    Reacts with: Human
    Does not react with: Mouse, Rat
  • Immunogen

    Synthetic peptide, corresponding to residues near the C-terminus of Human SCRIBBLE.

  • Positive control
    • 293T, HeLa and MCF7 cell lysates; permeabilized 293T cells.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents



Our Abpromise guarantee covers the use of ab125080 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 250 kDa (predicted molecular weight: 175 kDa).
ICC 1/100 - 1/250.
Flow Cyt 1/100 - 1/500.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

  • Application notes
    Is unsuitable for IHC-P or IP.
  • Target

    • Function
      Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.
    • Tissue specificity
      Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level).
    • Sequence similarities
      Belongs to the LAP (LRR and PDZ) protein family.
      Contains 16 LRR (leucine-rich) repeats.
      Contains 4 PDZ (DHR) domains.
    • Post-translational
      Ubiquitinated; targeted for UBE3A-dependent multiubiquitination in the presence of high-risk HPV E6 proteins and degraded.
    • Cellular localization
      Cell membrane. Cell junction > adherens junction. Cytoplasm. Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity. Localizes to neuronal post- and pre-synaptic regions.
    • Information by UniProt
    • Database links
    • Alternative names
      • CRIB 1 antibody
      • CRIB1 antibody
      • hScrib antibody
      • LAP 4 antibody
      • LAP4 antibody
      • PDZ domain protein scribble antibody
      • Protein LAP4 antibody
      • Protein scribble homolog antibody
      • SCRB 1 antibody
      • SCRB1 antibody
      • SCRIB 1 antibody
      • Scrib antibody
      • SCRIB_HUMAN antibody
      • SCRIB1 antibody
      • Scribble antibody
      • Scribble homolog 1 antibody
      • scribbled homolog (Drosophila) antibody
      • Vartul antibody
      see all


    • All lanes : Anti-SCRIBBLE antibody [EPR4140(2)] (ab125080) at 1/1000 dilution

      Lane 1 : 293T cell lysate
      Lane 2 : HeLa cell lysate
      Lane 3 : MCF7 cell lysate

      Lysates/proteins at 10 µg per lane.

      Goat anti-Rabbit HRP at 1/2000 dilution

      Predicted band size : 175 kDa
    • ab125080 at 1/100, staining SCRIBBLE in permeabilized 293T cells by flow cytometry (red), compared with a negative control Rabbit IgG antibody (green).


    ab125080 has not yet been referenced specifically in any publications.

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