Overview

  • Product name
    Anti-SCUBE1 antibody
  • Description
    Rabbit polyclonal to SCUBE1
  • Specificity
    ab105358 is predicted to not crossreact with other SCUBE members.
  • Tested applications
    Suitable for: ICC/IF, WB, ICCmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A 14 amino acid peptide near the center of Human SCUBE1 (NP_766638).

  • Positive control
    • WB: Daudi cell lysate ICC: Daudi cells

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab105358 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 108 kDa.
ICC Use a concentration of 20 µg/ml.

Target

  • Function
    Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology.
  • Tissue specificity
    Detected in endothelial cells. Highly expressed in platelets. Stored in platelet alpha granules, and transferrred to the cell surface upon activation and aggregation. A smaller form, probably produced by limited proteolysis, after being released from the storage granules, is associated with thrombus and localized with the subendothelial matrices in atherosclerotic plaques.
  • Sequence similarities
    Contains 1 CUB domain.
    Contains 9 EGF-like domains.
  • Post-translational
    modifications
    N-glycosylated.
    Could be proteolytically cleaved to release a smaller active fragment.
  • Cellular localization
    Secreted. Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • SCUB1_HUMAN antibody
    • SCUBE 1 antibody
    • SCUBE1 antibody
    • Signal peptide, CUB and EGF-like domain-containing protein 1 antibody
    • Signal peptide, CUB domain, EGF like 1 antibody
    see all

Images

  • Anti-SCUBE1 antibody (ab105358) at 1 µg/ml + Daudi cell lysate at 15 µg

    Predicted band size : 108 kDa
  • Immunocytochemical analysis of SCUBE1 in Daudi cells using ab105358 at 20 µg/ml.
  • Immunofluorescence of SCUBE1 in Daudi cells using ab105358 at 20 ug/ml.

References

This product has been referenced in:

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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