Anti-SDHB antibody (ab39988)

Overview

• Product name
  Anti-SDHB antibody
  See all SDHB primary antibodies
• Description
  Goat polyclonal to SDHB
• Tested applications
  Suitable for: WB, ELISAmore details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide:

  ATYKEKKASV

  , corresponding to C terminal amino acids 271/280 of Human SDHB

  Run BLAST with Run BLAST with
• Positive control
  • Human Liver lysate

Properties

• Form
  Liquid
• Storage instructions
  Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage buffer
  Preservative: 0.02% Sodium Azide
  Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
• Concentration information loading...
• Purity
  Immunogen affinity purified
• Purification notes
  Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
• Clonality
  Polyclonal
• Isotype
  IgG
• Research areas
  • Signal Transduction
  • Metabolism
  • Mitochondrial

  • Cell Biology
  • Other Antibodies
  • Oxidative Stress

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Metabolism of carbohydrates

  • Metabolism
  • Pathways and Processes
  • Mitochondrial Metabolism
  • Mitochondrial markers

  • Metabolism
  • Pathways and Processes
  • Redox metabolism
  • Oxidative stress

  • Metabolism
  • Pathways and Processes
  • Mitochondrial Metabolism
  • Oxidative phosphorylation
  • Complex II

  • Metabolism
  • Types of disease
  • Cancer

Associated products

• Compatible Secondaries
  • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
  • Donkey Anti-Goat IgG H&L (HRP) (ab205723)

Applications

Target

• Function
  Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
• Pathway
  Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
• Involvement in disease
  Defects in SDHB are a cause of susceptibility to pheochromocytoma (PCC) [MIM:171300]. A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent.
  Defects in SDHB are the cause of hereditary paragangliomas type 4 (PGL4) [MIM:115310]; also known as familial non-chromaffin paragangliomas type 4. Paragangliomas refer to rare and mostly benign tumors that arise from any component of the neuroendocrine system. PGL4 is characterized by the development of mostly benign, highly vascular, slow growing tumors in the head and neck. In the head and neck region, the carotid body is the largest of all paraganglia and is also the most common site of the tumors.
  Defects in SDHB are a cause of paraganglioma and gastric stromal sarcoma (PGGSS) [MIM:606864]; also called Carney-Stratakis syndrome. Gastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominant manner, alone or as a component of a syndrome associated with other tumors, such as in the context of neurofibromatosis type 1 (NF1). Patients have both gastrointestinal stromal tumors and paragangliomas. Susceptibility to the tumors was inherited in an apparently autosomal dominant manner, with incomplete penetrance.
  Defects in SDHB are a cause of Cowden-like syndrome (CWDLS) [MIM:612359]. Cowden-like syndrome is a cancer predisposition syndrome associated with elevated risk for tumors of the breast, thyroid, kidney and uterus.
• Sequence similarities
  Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
  Contains 1 2Fe-2S ferredoxin-type domain.
  Contains 1 4Fe-4S ferredoxin-type domain.
• Cellular localization
  Mitochondrion inner membrane.

• Target information above from: UniProt accession P21912 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 6390 Human
  • Omim: 185470 Human
  • SwissProt: P21912 Human
  • Unigene: 465924 Human
• Alternative names
  • CWS2 antibody
  • DHSB_HUMAN antibody
  • FLJ92337 antibody

  • Ip antibody
  • Iron sulfur subunit antibody
  • Iron sulfur subunit of complex II antibody
  • Iron-sulfur subunit of complex II antibody
  • mitochondrial antibody
  • PGL 4 antibody
  • PGL4 antibody
  • SDH 1 antibody
  • SDH antibody
  • SDH1 antibody
  • SDH2 antibody
  • SDH2, homolog of antibody
  • SdhB antibody
  • SDHIP antibody
  • Succinate dehydrogenase [ubiquinone] iron sulfur protein mitochondrial antibody
  • Succinate dehydrogenase [ubiquinone] iron sulfur subunit antibody
  • Succinate dehydrogenase [ubiquinone] iron-sulfur subunit antibody
  • succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial antibody
  • Succinate Dehydrogenase 1 Iron Sulfur Subunit antibody
  • Succinate Dehydrogenase 2, S. cerevisiae, homolog of antibody
  • Succinate dehydrogenase complex iron sulfur subunit B antibody
  • Succinate dehydrogenase complex subunit B iron sulfur antibody
  • Succinate Dehydrogenase Complex Subunit B Iron Sulfur Protein antibody
  • succinate dehydrogenase complex, subunit B, iron sulfur (Ip) antibody
  • Succinate dehydrogenase iron sulfur protein antibody

  see all

Protocols

• Western blot protocols