Overview

  • Product nameAnti-SDHC antibody
    See all SDHC primary antibodies
  • Description
    Rabbit polyclonal to SDHC
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 59-108 (YSWSLPMAMS ICHRGTGIAL SADVGPRKRP EDSPAIPVWS GCPGSYCVVL) of Human SDHC, isoform 2 (NP_001030588).

  • Positive control
    • THP1 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab125411 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 17 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionMembrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
  • PathwayCarbohydrate metabolism; tricarboxylic acid cycle.
  • Involvement in diseaseDefects in SDHC are the cause of hereditary paragangliomas type 3 (PGL3) [MIM:605373]; also known as autosomal dominant non-chromaffin paragangliomas type 3. Non-chromaffin paragangliomas are usually benign, neural crest derived tumors of parasympathetic ganglia.
    Defects in SDHC are a cause of paraganglioma and gastric stromal sarcoma (PGGSS) [MIM:606864]; also known as Carney-Stratakis syndrome. Gastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominant manner, alone or as a component of a syndrome associated with other tumors, such as in the context of neurofibromatosis type 1 (NF1). Patients have both gastrointestinal stromal tumors and paragangliomas. Susceptibility to the tumors was inherited in an apparently autosomal dominant manner, with incomplete penetrance.
  • Sequence similaritiesBelongs to the cytochrome b560 family.
  • Cellular localizationMitochondrion inner membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CYB560 antibody
    • C560_HUMAN antibody
    • CYBL antibody
    • Cytochrome B large subunit of complex II antibody
    • Integral membrane protein CII-3 antibody
    • mitochondrial antibody
    • PGL3 antibody
    • QPs-1 antibody
    • QPs1 antibody
    • SDH3 antibody
    • sdhC antibody
    • succinate dehydrgenase cytochrome b antibody
    • succinate dehydrogenase 3, integral membrane subunit antibody
    • Succinate dehydrogenase complex subunit C antibody
    • Succinate dehydrogenase complex subunit C integral membrane protein 15kDa antibody
    • Succinate dehydrogenase cytochrome b560 subunit antibody
    • Succinate dehydrogenase cytochrome b560 subunit mitochondrial antibody
    • Succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor antibody
    • Succinate-ubiquinone oxidoreductase cytochrome B large subunit antibody
    see all

Anti-SDHC antibody images

  • Anti-SDHC antibody (ab125411) at 1 µg/ml + THP1 cell lysate at 10 µg

    Predicted band size : 17 kDa

References for Anti-SDHC antibody (ab125411)

ab125411 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab125411.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"