Overview

  • Product name
  • Description
    Rabbit polyclonal to SDHC
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 59-108 (YSWSLPMAMS ICHRGTGIAL SADVGPRKRP EDSPAIPVWS GCPGSYCVVL) of Human SDHC, isoform 2 (NP_001030588).

  • Positive control
    • THP1 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab125411 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 17 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function
    Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
  • Pathway
    Carbohydrate metabolism; tricarboxylic acid cycle.
  • Involvement in disease
    Defects in SDHC are the cause of hereditary paragangliomas type 3 (PGL3) [MIM:605373]; also known as autosomal dominant non-chromaffin paragangliomas type 3. Non-chromaffin paragangliomas are usually benign, neural crest derived tumors of parasympathetic ganglia.
    Defects in SDHC are a cause of paraganglioma and gastric stromal sarcoma (PGGSS) [MIM:606864]; also known as Carney-Stratakis syndrome. Gastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominant manner, alone or as a component of a syndrome associated with other tumors, such as in the context of neurofibromatosis type 1 (NF1). Patients have both gastrointestinal stromal tumors and paragangliomas. Susceptibility to the tumors was inherited in an apparently autosomal dominant manner, with incomplete penetrance.
  • Sequence similarities
    Belongs to the cytochrome b560 family.
  • Cellular localization
    Mitochondrion inner membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CYB560 antibody
    • C560_HUMAN antibody
    • CYBL antibody
    • Cytochrome B large subunit of complex II antibody
    • Integral membrane protein CII-3 antibody
    • mitochondrial antibody
    • PGL3 antibody
    • QPs-1 antibody
    • QPs1 antibody
    • SDH3 antibody
    • sdhC antibody
    • succinate dehydrgenase cytochrome b antibody
    • succinate dehydrogenase 3, integral membrane subunit antibody
    • Succinate dehydrogenase complex subunit C antibody
    • Succinate dehydrogenase complex subunit C integral membrane protein 15kDa antibody
    • Succinate dehydrogenase cytochrome b560 subunit antibody
    • Succinate dehydrogenase cytochrome b560 subunit mitochondrial antibody
    • Succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor antibody
    • Succinate-ubiquinone oxidoreductase cytochrome B large subunit antibody
    see all

Images

  • Anti-SDHC antibody (ab125411) at 1 µg/ml + THP1 cell lysate at 10 µg

    Predicted band size : 17 kDa

References

ab125411 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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