Overview

  • Product name
  • Description
    Goat polyclonal to SDS3
  • Tested applications
    Suitable for: WB, IPmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rabbit, Chicken, Guinea pig, Cow, Dog, Turkey, Pig, Xenopus laevis, Chimpanzee, Zebrafish, Rhesus monkey, Gorilla, Orangutan, Xenopus tropicalis
  • Immunogen

    Synthetic peptide (Human) - which represented a portion of human Suppressor of Defective Silencing 3 encoded in part by exons 7 and 8.

  • Positive control
    • HeLa cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab3740 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Predicted molecular weight: 45 kDa.
IP Use at an assay dependent dilution. PubMed: 21239494

Target

  • Function
    Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways (By similarity). May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.
  • Tissue specificity
    Expressed in various cancer cell ines.
  • Sequence similarities
    Belongs to the SDS3 family.
  • Domain
    The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2400003N08Rik antibody
    • 2410008L21Rik antibody
    • 45 kDa Sin3 associated polypeptide antibody
    • 45 kDa Sin3-associated polypeptide antibody
    • AU067672 antibody
    • FLJ00052 antibody
    • MGC104711 antibody
    • mSds3 antibody
    • RGD1305986 antibody
    • SAP45 antibody
    • SDS3 antibody
    • SDS3, yeast, homolog of antibody
    • SDS3_HUMAN antibody
    • Sin3 histone deacetylase corepressor complex component SDS3 antibody
    • Sin3A associated protein 45kDa antibody
    • Suds3 antibody
    • Suppressor of defective silencing 3 antibody
    • Suppressor of defective silencing 3 homolog (S cerevisiae) antibody
    • Suppressor of defective silencing 3 homolog (SDS3 S cerevisiae) antibody
    • Suppressor of defective silencing 3 protein homolog antibody
    see all

Images



  • Predicted band size : 45 kDa


    Sample: HeLa whole cell lysate (50µg/lane)

    Antibody: Affinity purified Goat anti-SDS 3 (ab3740) used at the concentrations indicated.

    Detection: ECL exposed for 2 minutes.

References

This product has been referenced in:
  • Ramakrishna S  et al. Hyaluronan Binding Motifs of USP17 and SDS3 Exhibit Anti-Tumor Activity. PLoS One 7:e37772 (2012). WB ; Human . Read more (PubMed: 22662218) »
  • Ramakrishna S  et al. K63 specific deubiquitination of SDS3 by USP17 regulates HDAC activity. J Biol Chem : (2011). IP ; Human . Read more (PubMed: 21239494) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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