General notesab94303 is a 293T cell transfected lysate in which Human SDS3 has been transiently over-expressed using a pCMV-SDS3 plasmid. The lysate is provided in 1X Sample Buffer.
Note: For more detailed how the transfected lysate was prepared view preparation notes
BackgroundFunction: Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways (By similarity). May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.
Tissue specificity: Expressed in various cancer cell ines.
Similarity: Belongs to the SDS3 family.
Domain: The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms.