Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SequenceAn 18 amino acid synthetic peptide whose sequences are derived from rat COP II protein. The sequence of this peptide is (amino to carboxy terminus): M(1)TTYLEFIQQNEERDGVR(18) - C.

Specifications

Our Abpromise guarantee covers the use of ab4960 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Additional notes


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and rat COP II, catalog ab3351. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

General Info

  • Alternative names
    • CLSD
    • Protein transport protein Sec23A
    • SC23A_HUMAN
    • Sec23 homolog A (S. cerevisiae)
    • SEC23-related protein A
    • sec23a
    see all
  • FunctionComponent of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.
  • Involvement in diseaseDefects in SEC23A are the cause of craniolenticulosutural dysplasia (CLSD) [MIM:607812]; also known as cranio-lenticulo-sutural dysplasia. CLSD is an autosomal recessive syndrome characterized by late-closing fontanels, sutural cataracts, facial dysmorphisms and skeletal defects.
  • Sequence similaritiesBelongs to the SEC23/SEC24 family. SEC23 subfamily.
  • Cellular localizationSmooth endoplasmic reticulum membrane. Golgi apparatus membrane. In the ribosome-free transitional face of the ER and associated vesicles.
  • Information by UniProt

References for SEC23 peptide (ab4960)

ab4960 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab4960.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"