Overview

  • Product name
  • Description
    Mouse polyclonal to SEC63
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length SEC63 protein (Human) (NP_009145.1).

  • Positive control
    • Human pancreas lysate, SEC63 transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab68550 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 88 kDa (predicted molecular weight: 88 kDa).

Target

  • Relevance
    SEC63 and SEC62 proteins are found to be associated with the ribosome-free SEC61 complex, which is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. Mutations in SEC63 cause autosomal dominant polycystic liver disease.
  • Cellular localization
    Endoplasmic reticulum membrane; Multi pass membrane protein.
  • Database links
  • Alternative names
    • ERdj2 antibody
    • PRO2507 antibody
    • SEC 63 antibody
    • SEC63L antibody
    • Translocation protein SEC63 homolog antibody
    see all

Images

  • Anti-SEC63 antibody (ab68550) at 1/500 dilution + Human pancreas lysate at 50 µg

    Secondary
    Goat Anti-Mouse IgG (H&L) at 1/2500 dilution

    Predicted band size : 88 kDa
    Observed band size : 88 kDa
  • All lanes : Anti-SEC63 antibody (ab68550) at 1/500 dilution

    Lane 1 : SEC63 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L) at 1/2500 dilution

    Predicted band size : 88 kDa
    Observed band size : 88 kDa

References

ab68550 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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