Overview

  • Product nameAnti-SEC63 antibody
    See all SEC63 primary antibodies
  • Description
    Rabbit polyclonal to SEC63
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 35-84 (WPRDQNAEQI RLKNIRKVYG RCMWYRLRLL KPQPNIIPTV KKIVLLAGWA) of Human SEC63 (NP_009145).

  • Positive control
    • THP1 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab99031 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 88 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • RelevanceSEC63 and SEC62 proteins are found to be associated with the ribosome-free SEC61 complex, which is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. Mutations in SEC63 cause autosomal dominant polycystic liver disease.
  • Cellular localizationEndoplasmic reticulum membrane; Multi pass membrane protein.
  • Database links
  • Alternative names
    • ERdj2 antibody
    • PRO2507 antibody
    • SEC 63 antibody
    • SEC63L antibody
    • Translocation protein SEC63 homolog antibody
    see all

Anti-SEC63 antibody images

  • Anti-SEC63 antibody (ab99031) at 1 µg/ml + THP1 cell lysate at 10 µg

    Predicted band size : 88 kDa

References for Anti-SEC63 antibody (ab99031)

ab99031 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"