Anti-Secretory Component Glycoprotein antibody [COMPO2], prediluted (ab75232)

Overview

  • Product nameAnti-Secretory Component Glycoprotein antibody [COMPO2], prediluted
    See all Secretory Component Glycoprotein primary antibodies
  • Description
    Mouse monoclonal [COMPO2] to Secretory Component Glycoprotein, prediluted
  • Specificityab75232 reacts with both free and polymeric Ig-bound Secretory Component Glycoprotein.
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Full length native Secretory Component Glycoprotein (semi-purified) (Human)

  • Positive control
    • Stomach, small intestine, colon carcinoma.
  • General notesClone designation COMPO2 is the same as SC-05.

Properties

Applications

Our Abpromise guarantee covers the use of ab75232 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: Ready-to-use. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 min.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionInvolved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.
    • Tissue specificityExpressed in breast cancer tissues. Little or no expression observed in normal breast tissues. Expressed in skin; wide expression is observed throughout the dermis with minimal expression in the epidermis.
    • Involvement in diseaseDefects in ECM1 are the cause of lipoid proteinosis (LiP) [MIM:247100]; also known as lipoid proteinosis of Urbach and Wiethe or hyalinosis cutis et mucosae. LiP is a rare autosomal recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane.
    • Cellular localizationSecreted > extracellular space > extracellular matrix.
    • Information by UniProt
    • Database links
    • Alternative names
      • ECM 1 antibody
      • Ecm1 antibody
      • ECM1_HUMAN antibody
      • Extracellular matrix protein 1 antibody
      • Secretory component p85 antibody
      • URBWD antibody
      see all

    Anti-Secretory Component Glycoprotein antibody [COMPO2], prediluted images

    • Formalin-fixed, paraffin-embedded human colon carcinoma stained with ab75232, using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of tumor cells.

    References for Anti-Secretory Component Glycoprotein antibody [COMPO2], prediluted (ab75232)

    ab75232 has not yet been referenced specifically in any publications.

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