Anti-Secretory Component Glycoprotein antibody [SPM217] (ab17921)

Overview

  • Product nameAnti-Secretory Component Glycoprotein antibody [SPM217]
    See all Secretory Component Glycoprotein primary antibodies
  • Description
    Mouse monoclonal [SPM217] to Secretory Component Glycoprotein
  • Tested applicationsSuitable for: ICC/IF, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat
  • Immunogen

    Full length native protein (purified) (Human).

  • EpitopeNot determined
  • Positive control
    • Small intestine. Colon carcinoma

Properties

Applications

Our Abpromise guarantee covers the use of ab17921 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF
IHC-P
  • Application notes
    IF: Use at an assay dependent dilution.
    IHC-P: 1/50. Perform enzymatic antigen retrieval before commencing with IHC staining protocol. For staining of formalin-fixed tissues, digest sections with trypsin at 1mg/ml PBS, 15 min at room temp.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionInvolved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.
    • Tissue specificityExpressed in breast cancer tissues. Little or no expression observed in normal breast tissues. Expressed in skin; wide expression is observed throughout the dermis with minimal expression in the epidermis.
    • Involvement in diseaseDefects in ECM1 are the cause of lipoid proteinosis (LiP) [MIM:247100]; also known as lipoid proteinosis of Urbach and Wiethe or hyalinosis cutis et mucosae. LiP is a rare autosomal recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane.
    • Cellular localizationSecreted > extracellular space > extracellular matrix.
    • Information by UniProt
    • Database links
    • Alternative names
      • ECM 1 antibody
      • Ecm1 antibody
      • ECM1_HUMAN antibody
      • Extracellular matrix protein 1 antibody
      • Secretory component p85 antibody
      • URBWD antibody
      see all

    Anti-Secretory Component Glycoprotein antibody [SPM217] images

    • Human colon carcinoma stained with ab17921.

    References for Anti-Secretory Component Glycoprotein antibody [SPM217] (ab17921)

    ab17921 has not yet been referenced specifically in any publications.

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