Overview

  • Product nameAnti-Seladin 1 antibody
    See all Seladin 1 primary antibodies
  • Description
    Rabbit polyclonal to Seladin 1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 431-480 (AELYIDIGAY GEPRVKHFEA RSCMRQLEKF VRSVHGFQML YADCYMNREE) of Human Seladin 1 (NP_055577).

  • Positive control
    • THP1 cell lysate

Applications

Our Abpromise guarantee covers the use of ab98345 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 60 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionCatalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis.
  • Tissue specificityHighly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex.
  • PathwaySteroid biosynthesis; cholesterol biosynthesis.
  • Involvement in diseaseDesmosterolosis (DESMOS) [MIM:602398]: Rare autosomal recessive disorder characterized by multiple congenital anomalies and elevated levels of the cholesterol precursor desmosterol in plasma, tissue, and cultured cells. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Sequence similaritiesBelongs to the FAD-binding oxidoreductase/transferase type 4 family.
    Contains 1 FAD-binding PCMH-type domain.
  • Cellular localizationEndoplasmic reticulum membrane. Golgi apparatus membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 24 dehydrocholesterol reductase antibody
    • 24-dehydrocholesterol reductase antibody
    • 3 beta hydroxysterol delta 24 reductase antibody
    • 3-beta-hydroxysterol delta-24-reductase antibody
    • DCE antibody
    • Delta(24)-sterol reductase antibody
    • Desmosterol to cholesterol enzyme antibody
    • DHC24_HUMAN antibody
    • Dhcr24 antibody
    • Diminuto dwarf1 homolog antibody
    • Diminuto/dwarf1 homolog antibody
    • KIAA0018 antibody
    • Nbla03646 antibody
    • Seladin-1 antibody
    • SELADIN1 antibody
    • Selective AD indicator 1 antibody
    • Selective Alzheimer's Disease Indicator 1 antibody
    see all

Anti-Seladin 1 antibody images

  • Anti-Seladin 1 antibody (ab98345) at 1 µg/ml + THP1 cell lysate at 10 µg

    Predicted band size : 60 kDa

References for Anti-Seladin 1 antibody (ab98345)

ab98345 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab98345.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"