Overview

  • Product nameAnti-SELS antibody - Aminoterminal end
    See all SELS primary antibodies
  • Description
    Rabbit polyclonal to SELS - Aminoterminal end
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to N-terminal residues of human SELS

Properties

Applications

Our Abpromise guarantee covers the use of ab58656 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 21 kDa.
ELISA Use at an assay dependent dilution.

Target

  • RelevanceInvolved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.
  • Cellular localizationEndoplasmic reticulum; endoplasmic reticulum membrane; single pass membrane protein.
  • Database links
  • Alternative names
    • AD-015 antibody
    • ADO15 antibody
    • MGC104346 antibody
    • MGC2553 antibody
    • SBBI8 antibody
    • selenoprotein S antibody
    • SEPS1 antibody
    • VCP interacting membrane protein antibody
    • VCP-interacting membrane antibody
    • VIMP antibody
    see all

References for Anti-SELS antibody - Aminoterminal end (ab58656)

This product has been referenced in:
  • Schoenmakers E  et al. Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans. J Clin Invest 120:4220-35 (2010). WB ; Human . Read more (PubMed: 21084748) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"