Overview

  • Product nameAnti-Semaphorin 7a antibody [MEM-150]
    See all Semaphorin 7a primary antibodies
  • Description
    Mouse monoclonal [MEM-150] to Semaphorin 7a
  • SpecificityHuman CD108 (JMH blood group antigen).
  • Tested applicationsSuitable for: ICC/IF, Flow Cyt, IP, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Tissue/ cell preparation (Human). (T cell line HPB-ALL).

Properties

Applications

Our Abpromise guarantee covers the use of ab8222 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use at an assay dependent concentration. PubMed: 22896629
Flow Cyt Use a concentration of 4 µg/ml. ab91545-Mouse monoclonal IgM, is suitable for use as an isotype control with this antibody.
IP Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Use under non-reducing conditions.

Target

  • FunctionPlays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
  • Tissue specificityDetected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney.
  • Sequence similaritiesBelongs to the semaphorin family.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 PSI domain.
    Contains 1 Sema domain.
  • Cellular localizationCell membrane. Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD 108 antibody
    • CD108 antibody
    • CD108 antigen antibody
    • CDw108 antibody
    • H Sema K1 antibody
    • H Sema L antibody
    • H-SEMA-K1 antibody
    • H-Sema-L antibody
    • JMH antibody
    • JMH blood group antigen antibody
    • John Milton Hagen blood group H Sema K1 antibody
    • John Milton Hargen human blood group Ag antibody
    • John-Milton-Hargen human blood group Ag antibody
    • MGC126692 antibody
    • MGC126696 antibody
    • SEM7A_HUMAN antibody
    • Sema domain immunoglobulin domain (Ig) and GPI membrane anchor 7A antibody
    • Sema K1 antibody
    • Sema L antibody
    • SEMA7A antibody
    • SEMAK1 antibody
    • SEMAL antibody
    • Semaphorin 7A GPI membrane anchor antibody
    • Semaphorin K1 antibody
    • Semaphorin L antibody
    • Semaphorin-7A antibody
    • Semaphorin-K1 antibody
    • Semaphorin-L antibody
    • Semaphorin7a antibody
    see all

References for Anti-Semaphorin 7a antibody [MEM-150] (ab8222)

This product has been referenced in:
  • Drukker M  et al. Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells. Nat Biotechnol 30:531-42 (2012). Human . Read more (PubMed: 22634564) »
  • Sultana H  et al. Semaphorin 7A contributes to West Nile virus pathogenesis through TGF-ß1/Smad6 signaling. J Immunol 189:3150-8 (2012). WB, ICC/IF ; Mouse . Read more (PubMed: 22896629) »

See all 6 Publications for this product

Product Wall

You are indeed correct. MEM-150 produces an IgM antibody. We are grateful that you brought it to our attention. Many thanks.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"