Overview

  • Product nameAnti-SEN1 antibody
  • Description
    Rabbit polyclonal to SEN1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 186-235 (LAYTPLNEKS LALLLNYLHD FLKYLAKNSA TLFSASDYEV ALPEYHRKAV) of Human SEN1 (NP_006783).

  • Positive control
    • Human fetal muscle lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab84703 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 27 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • RelevanceCellular senescence, the terminal nondividing state that normal cells enter following completion of their proliferative potential, is the dominant phenotype in hybrids of normal and immortal cells. Fusions of immortal human cell lines with each other have led to their assignment to one of several complementation groups. SEN1 or MORF4 is a gene on chromosome 4 that induces a senescent-like phenotype in cell lines assigned to complementation group B. It is capable of reversing the immortal phenotype of a subset of immortal cells. Overexpression of SEN1 in HeLa cells ultimately caused abnormal nuclear morphology and cell death.
  • Cellular localizationNuclear
  • Database links
  • Alternative names
    • Cell senescence related gene complementation group B antibody
    • Cellular senescence related protein 1 antibody
    • CSR antibody
    • CSRB antibody
    • MORF 4 antibody
    • MORF4 antibody
    • MORF4 protein antibody
    • Mortality factor 4 antibody
    • SEN 1 antibody
    • SEN antibody
    • Senescence (cellular) related 1 antibody
    • Senescence related cellular 1 antibody
    • Transcription factor like protein MORF4 antibody
    see all

Anti-SEN1 antibody images

  • Anti-SEN1 antibody (ab84703) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal muscle lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 27 kDa
    Observed band size : 29 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 20 kDa. We are unsure as to the identity of these extra bands.

References for Anti-SEN1 antibody (ab84703)

ab84703 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"