Overview

  • Product name
    Sennoside A
  • Description
    Moderate non-competitive bovine MAO inhibitor
  • Biological description
    Moderate non-competitive bovine MAO inhibitor (IC50 = 17 μM). Sennoside B (ab145727) analog. Shows laxative effects in vivo. Orally active.

Properties

  • Chemical name
    (9R)-9-[(9R)-2-Carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic acid
  • Molecular weight
    862.74
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C42H38O20
  • CAS Number
    81-27-6
  • PubChem identifier
    73111
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C1=CC2=C(C(=C1)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)C(=O)C4=C([C@@H]2[C@@H]5C6=C(C(=CC=C6)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)C(=O)C8=C5C=C(C=C8O)C(=O)O)C=C(C=C4O)C(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Kon R  et al. Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract. J Ethnopharmacol 152:190-200 (2014). Read more (PubMed: 24412547) »
  • Takayama K  et al. The influence of rhein 8-O-ß-D-glucopyranoside on the purgative action of sennoside A from rhubarb in mice. Biol Pharm Bull 35:2204-8 (2012). Read more (PubMed: 23207772) »
  • Hiraoka A  et al. The sennoside constituents of rhei rhizoma and sennae folium as inhibitors of serum monoamine oxidase. Chem Pharm Bull (Tokyo) 37:2744-6 (1989). Read more (PubMed: 2611933) »

See 0 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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