Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity.
Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine.
Belongs to the peptidase C48 family.
Nucleus. Cytoplasm. Shuttles between cytoplasm and nucleus.
Western blot analysis SENP 1 in whole HL60 cell lysate. SENP1 (Arrow) was detected using ab3656 (Lane B) but not pre-immune serum (lane A). Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Ni RS et al. Detection of differentially expressed genes and association with clinicopathological features in laryngeal squamous cell carcinoma. Oncol Lett4:1354-1360 (2012).
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Dai XQ et al. SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans. Diabetes60:838-47 (2011).
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