Overview

  • Product nameAnti-SENP2 antibody
    See all SENP2 primary antibodies
  • Description
    Rabbit polyclonal to SENP2
  • Tested applicationsSuitable for: WB, IPmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Bat
  • Immunogen

    Synthetic peptide, corresponding to a region between residue 150 and 200 of Human SENP2 (NP_067640.2)

  • Positive control
    • Whole cell lysate from HeLa or 293T cells

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab109590 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000 - 1/10000. Predicted molecular weight: 68 kDa.
IP Use at 2-5 µg/mg of lysate.

Target

  • FunctionProtease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway.
  • Sequence similaritiesBelongs to the peptidase C48 family.
  • DomainThe N-terminus is necessary and sufficient for nuclear envelope targeting.
  • Post-translational
    modifications
    Polyubiquitinated; which leads to proteasomal degradation.
  • Cellular localizationNucleus > nuclear pore complex. Nucleus membrane. Cytoplasm. Shuttles between cytoplasm and nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Axam2 antibody
    • DKFZp762A2316 antibody
    • KIAA1331 antibody
    • Senp2 antibody
    • SENP2_HUMAN antibody
    • Sentrin specific protease 2 antibody
    • Sentrin-specific protease 2 antibody
    • Sentrin/SUMO specific protease SENP2 antibody
    • Sentrin/SUMO-specific protease SENP2 antibody
    • SMT3 specific isopeptidase 2 antibody
    • SMT3-specific isopeptidase 2 antibody
    • Smt3ip2 antibody
    • SUMO1/sentrin/SMT3 specific peptidase 2 antibody
    see all

Anti-SENP2 antibody images

  • All lanes : Anti-SENP2 antibody (ab109590) at 0.1 µg/ml

    Lane 1 : HeLa whole cell lysate at 50 µg
    Lane 2 : HeLa whole cell lysate at 15 µg
    Lane 3 : HeLa whole cell lysate at 5 µg
    Lane 4 : 293T whole cell lysate at 50 µg

    Developed using the ECL technique

    Predicted band size : 68 kDa


    Exposure time : 3 minutes
  • Detection of SENP2 by Western Blot of Immunprecipitate.
    ab109590 at 1µg/ml staining SENP2 in HeLa whole cell lysate immunoprecipitated using ab109590 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with exposure time of 30 seconds.

References for Anti-SENP2 antibody (ab109590)

ab109590 has not yet been referenced specifically in any publications.

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